J. Huang

IR-B deficiency and fatty acid dysregulation accelerate prostate cancer progression via PI3K/AKT signaling

This study shows that IR-B deficiency in prostate cancer accelerates tumor progression through PI3K/AKT signaling and fatty acid dysregulation, with omega-3 fatty acids having opposing effects.

Discovery of potent oligopeptides for various metabolic diseases using deep learning

This paper introduces Deepeptide, a deep learning pipeline that identifies therapeutic oligopeptides for metabolic diseases, finding 62% of candidates show significant in vitro bioactivity comparable to first-line drugs.

Focus-Tunable Two-Photon Fiberscope Enabling in vivo Imaging at Selected Depths

This paper introduces a two-photon fiberscope with tunable focus for in vivo imaging at selected depths, demonstrating its performance using phantoms and biological samples.

SBT5.2s are the major active extracellular subtilases processing IgG antibody 2F5 in the Nicotiana benthamiana apoplast

The paper shows that SBT5.2 subtilases degrade the IgG antibody 2F5 in Nicotiana benthamiana apoplast, and their knockout increases 2F5 accumulation without affecting plant growth.

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation

This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Developing Bioactive Hydrogels Containing Cell-derived Extracellular Matrix: Implications in Drug and Cell-free Bone and Cartilage Repair

This study develops bioactive hydrogels containing cell-derived extracellular matrix for drug-free and cell-free bone and cartilage repair, showing induction of stem cell differentiation.

DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

This study profiles the DNA methylome of Pseudomonas syringae and shows its role in regulating virulence and metabolism through 6mA methylation.

Genomic and environmental controls on Castellaniella biogeography in an anthropogenically disturbed subsurface

This study investigates how genomic and environmental factors influence the distribution of Castellaniella species in a contaminated subsurface, identifying genetic mechanisms underlying their adaptation to stress.

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

The paper maps the transcriptional regulatory network of Pseudomonas syringae, identifying hierarchical TF organization and functional roles in virulence and metabolism.

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

This study uses single-cell transcriptomics to identify cell type-specific immune responses in a mouse model of allergic contact dermatitis, highlighting the role of dermal fibroblasts in type-1 inflammation.

Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

This study identifies molecular and ecological adaptations in the parasitoid Trichopria drosophilae that enhance its success in parasitizing Drosophila hosts.

Simultaneous generation of osteoblasts and adipocytes by a bivalent differentiation medium from bone marrow stromal/stem cells (BMSCs)

This paper introduces a bivalent differentiation medium that enables BMSCs to simultaneously generate osteoblasts and adipocytes, with a method to assess lineage commitment using staining techniques.

Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints

This study identifies NGFR's role in limiting inflammation to promote joint remodeling and repair in osteoarthritis by modulating NF-κB and BMP-SMAD1 signaling.

Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder

This study tracks immune cell changes in a KRASG12C NSCLC patient during sotorasib treatment and resistance, showing fluctuations in CD8+CD161hi T cells.

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

This study evaluates a recombinant BCG strain that releases a STING agonist, showing improved antitumor efficacy in bladder cancer models compared to wild-type BCG.

The Arabidopsis PPR protein EMB1006 interacts with both EMB1270 and CFM2 to facilitate plastid clpP1 intron2 splicing

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Expansion of human hematopoietic stem cells by inhibiting translation

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

The paper investigates the onset of anharmonicity in a protein and its surface water around 200 K, finding they are decoupled, with the protein's transition being intrinsic and the water's being a resolution effect.

DP/MM: A Hybrid Model for Zinc-Protein Interactions in Molecular Dynamics

This paper introduces DP/MM, a hybrid model for zinc-protein interactions that improves accuracy and efficiency in molecular dynamics simulations.

Natural genomic variation in rice blast genomes is associated with specific heterochromatinmodifications

The paper examines DNA sequence variation in rice blast fungi, finding that heterochromatin-associated histone marks correlate with SNP and INDEL frequency, even after accounting for selection.

Stratification of enterochromaffin cells by single-cell expression analysis

This study identifies fourteen enterochromaffin cell clusters in the gut using single-cell transcriptomics and spatial analysis, revealing subtypes with distinct functional properties and a Piezo2+ population involved in colon motility.

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes

This study identifies EZH2 as a dependency in NUT carcinoma, showing that combining EZH2 and BET inhibitors synergistically blocks tumor growth and prolongs survival.

Cigarette smoking promotes the spread of antimicrobial resistance in the human lung and the environment

This study shows cigarette smoke increases antimicrobial resistance transfer between bacteria in lung and environmental settings.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.