S. S. Davies

The paper identifies post-translationally modified self-peptides linked to hypertension using a combined computational and experimental approach.

This study identifies small molecule activators of NAPE-PLD that enhance efferocytosis by macrophages, suggesting their potential therapeutic use in cardiometabolic diseases.

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

This study identifies symmetrically substituted dichlorophenes as potent and selective inhibitors of NAPE-PLD, with IC50 values around 2 M.

This study shows that 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic mice by scavenging reactive dicarbonyls and improving HDL function.

This study identifies elevated 4-oxo-2-nonenal (ONE) adducts in HDL from familial hypercholesterolemia patients and shows their functional impact on HDL function and macrophage responses.

This study shows that reactive dicarbonyl scavengers reduce MPO-mediated HDL oxidation, preserve HDL function, and improve cholesterol efflux in FH-HDL and mice.