Combining Cell-Intrinsic and -Extrinsic Resistance to HIV-1 By Engineering Hematopoietic Stem Cells for CCR5 Knockout and B Cell Secretion of Therapeutic Antibodies
W. N. Feist, S. E. Luna, K. Ben-Efraim, M. V. Filsinger Interrante, N. A. Amorin, N. M. Johnston, T. U. J. Bruun, H. Y. Ghanim, B. J. Lesch, A. M. Dudek, M. H. Porteus
This paper describes engineering hematopoietic stem cells to produce CCR5 knockout cells and secrete HIV-1 inhibiting antibodies, aiming for a one-time cure for HIV-1.
bioRxiv · Mar 8, 2024 · PreprintBioengineering