A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells
C. B. Raeburn, A. R. Ormsby, N. S. Moily, D. Cox, S. Ebbinghaus, A. Dickson, G. McColl, D. M. Hatters
The paper develops a biosensor to compare protein homeostasis resilience in the nucleus and cytosol of human cells, finding the nucleus has lower chaperone activity and aggregation suppression capacity.
bioRxiv · Apr 19, 2021 · PreprintBiochemistry