D. Cox

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

FAK family proteins regulate in vivo breast cancer metastasis via distinct mechanisms.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.

Four-dimensional quantitative analysis of cell plate development using lattice light sheet microscopy identifies robust transition points between growth phases

This study uses lattice light sheet microscopy to analyze cell plate development in four dimensions, identifying phase transitions and the role of callose in cytokinesis.

Characterization and super-resolution imaging of small tau aggregates in human samples.

The paper develops a method to detect and characterize small tau aggregates in human samples, revealing disease-specific morphological and compositional differences.

Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections

This study shows macrophages promote tumor cell extravasation via thin membranous connections (TMCs) in vitro and in vivo, and reducing TMC formation decreases metastasis.

Replicative aging impedes stress-induced assembly of a key human protein disaggregase

This study identifies a stress-induced trimeric protein disaggregase in human cells that collapses during replicative aging, contributing to pathophysiological consequences.

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli.

The paper uses protein painting to show how pharmacological stimuli remodel conserved proteostasis machinery across the proteome in whole cells.

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

This study isolates monoclonal antibodies from a vaccinated individual and shows they neutralize multiple SARS-CoV-2 variants effectively.

Sequence grammar underlying unfolding and phase separation of globular proteins

The paper investigates how sequence grammars of unfolded globular proteins drive phase separation and formation of UPODs, highlighting the role of hydrophobic residues and their impact on disease-related interactions.

Virulence determinant, PTP7, controls vesicle budding from the Maurers clefts, adhesin protein trafficking and host cell remodeling in Plasmodium falciparum

A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells

The paper develops a biosensor to compare protein homeostasis resilience in the nucleus and cytosol of human cells, finding the nucleus has lower chaperone activity and aggregation suppression capacity.

Hidden information on protein function in censuses of proteome foldedness

The paper shows proteome folding stability censuses are unreliable due to hidden information on conformation and ligand binding.

A Biophysical Model for Plant Cell Plate Development

This paper develops a biophysical model to understand the role of callose in plant cell plate development, showing that a spreading force is necessary for proper maturation.

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

This study investigates how mutant Huntingtin exon 1 chains form inclusions in cells, finding that nascent chains do not stall on ribosomes but that ribosome quality control proteins are recruited into the aggregates.

Spatio-temporal mapping of mechanical force generated by macrophages during FcγR-dependent phagocytosis reveals adaptation to target stiffness

This study uses Traction Force Microscopy to analyze how macrophages adapt their mechanical forces during FcγR-dependent phagocytosis based on target stiffness.

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells

This study shows that neurodegenerative disease-associated protein aggregates fail to induce the heat shock response in neuronal-like cells, unlike non-pathogenic aggregation-prone proteins.

Investigations into the declining health of alder (Alnus glutinosa) along the river Lagan in Belfast, including the first report of Phytophthora lacustris causing disease of Alnus in Northern Ireland

The paper surveys alder trees along the river Lagan in Belfast, identifying Phytophthora lacustris as a new pathogen causing disease in Alnus glutinosa in Northern Ireland.

Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

This study shows that arginine valency in C9ORF72 DPRs causes promiscuous proteome binding, ribosome stalling, actin cytoskeleton disruption, and arginine hypomethylation.

ETHYLENE RESPONSE FACTOR (ERF) genes modulate plant root exudate composition and the attraction of plant parasitic nematodes

This study shows that knocking down ERF-E2 in tomato increases root exudate attractiveness to certain plant parasitic nematodes but not others, while ERF-E3 knockdown has no effect.

ABC transporters alter plant-microbe-parasite interactions in the rhizosphere

This study shows that knocking down ABC transporters in tomato alters root exudate composition, repelling plant-parasitic nematodes while retaining attraction of beneficial bacteria.

Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles

This study identifies transcriptional differences and microRNA variation associated with host-finding behaviour variation in Steinernema carpocapsae strains.