The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia
S. Enlund, I. Sinha, C. Neofytou, A. Ramilo Amor, K. Papadakis, A. Nilsson, Q. Jiang, O. Hermanson, F. Holm
The paper identifies dysregulated gene expression and epigenetic changes in CNS infiltrated T-ALL that promote survival and relapse, offering potential targets for therapy.
bioRxiv · Sep 1, 2023Cancer Biology