The paper uses single-cell sequencing to analyze CAR signaling and identifies ICD architectures that promote durable in vivo persistence in liquid tumors.

bioRxiv · Apr 29, 2024Immunology

The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia

S. Enlund, I. Sinha, C. Neofytou, A. Ramilo Amor, K. Papadakis, A. Nilsson, Q. Jiang, O. Hermanson, F. Holm

The paper identifies dysregulated gene expression and epigenetic changes in CNS infiltrated T-ALL that promote survival and relapse, offering potential targets for therapy.

bioRxiv · Sep 1, 2023Cancer Biology

Multidimensional Characterization of Soft-Tissue Sarcomas with FUS-TFCP2 or EWSR1-TFCP2 Fusions

J. Schopf, S. Uhrig, C. E. Heilig, K.-S. Lee, T. Walther, A. Carazzato, A. M. Dobberkau, D. Weichenhan, C. Plass, M. Hartmann, G. D. Diwan, Z. Carrero, C. R. Ball, T. Hohl, T. Kindler, , C. Scholl

This study characterizes soft-tissue sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions through multi-omics analyses and functional studies, identifying therapeutic targets and mechanisms of disease.

bioRxiv · Feb 19, 2023Cancer Biology

Efficacy of two commercial disinfectants on Paenibacillus larvae spores

J. Kiriamburi, A. Nilsson, J. Muturi, J. Mugweru, E. Forsgren

This study compares the efficacy of two disinfectants against Paenibacillus larvae spores on different beehive materials.

bioRxiv · Mar 16, 2021Microbiology