Q. Jiang

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

This study identifies a gut microbiome-derived peptide that mimics a myelin antigen and induces experimental autoimmune encephalomyelitis in mice.

TLCellClassifier: Machine Learning Based Cell Classification for Bright-Field Time-Lapse Images

TLCellClassifier improves cell detection, tracking, and classification in time-lapse images using CNN, metric learning, and LSTM, outperforming existing tools in accuracy and efficiency.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

Rapid High-Throughput Isolation and purification of Chicken Myoblasts Based on Deterministic Lateral Displacement Microfluidic Chips

This study develops a microfluidic platform for isolating chicken myoblasts using deterministic lateral displacement, achieving 80% recovery and 99% purity.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos

This study identifies circatidal gene expression rhythms in the deep-sea shrimp Rimicaris leurokolos, revealing a 12-hour oscillation pattern distinct from circadian rhythms and similar to ultradian rhythms in other species.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia

The paper identifies dysregulated gene expression and epigenetic changes in CNS infiltrated T-ALL that promote survival and relapse, offering potential targets for therapy.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

SMB controls decompartmentalization in Arabidopsis root cap cells to execute programmed cell death

The paper identifies SMB-controlled decompartmentalization events and ion fluxes in Arabidopsis root cap cells that execute programmed cell death.

DNA binding activity of CAMTA3 is essential for its function

This study shows that DNA-binding activity is essential for CAMTA3's role in plant immune responses, contradicting previous claims that transcriptional activity was unnecessary.

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

The paper investigates the role of intrinsically disordered CsoS2 in α-carboxysome shell assembly using synthetic engineering and cryoEM structures, revealing its function as a molecular thread and identifying a conserved interaction motif.

Effect of Intermittent Pneumatic Compression on Preventing Deep Vein Thrombosis Using Microfluidic Vein Chip

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

A comprehensive catalog with 100 million genes and 3,000 metagenome-assembled genomes from global cold seep sediments

The paper constructs a comprehensive gene and genome catalog from cold seep sediments, revealing novel microbial species and a large fraction of uncharacterized genes.

NuSAP participates in metaphase spindle length control in mammalians

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

TPLATE complex dependent endocytosis is required for shoot apical meristem maintenance by 1 attenuating CLAVATA1 signaling

The paper investigates the role of TPLATE complex-dependent endocytosis in regulating CLAVATA1 signaling in Arabidopsis shoot apical meristem maintenance.

Transcriptomics based prediction of survival and response to therapy in malignant mesothelioma

The paper identifies a 48-gene prognostic signature and synthetic-lethality profiles predictive of survival and therapy response in mesothelioma using transcriptomic and exomic data from 122 patients.

Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

Effect of Aeromonas hydrophila infected on metabolomic response and gut microbial 16S rRna of Charybdis japonica

This study investigates how Aeromonas hydrophila infection affects the metabolomic response and gut microbiota of Charybdis japonica, showing that certain bacteria and metabolites help resist infection.

CAR-NK Cells Effectively Target the D614 and G614 SARS-CoV-2-infected Cells

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

Converting Muscle-mimetic Biomaterials to Cartilage-like Materials

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

YTHDF1 drives intestinal immune response against bacterial infection

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

Evolution and variation of 2019-novel coronavirus

The paper analyzes the evolution and variation of 2019-nCoV by comparing genomic sequences from multiple isolates, identifying amino acid variations and estimating the molecular clock and most recent common ancestor.

Identification of QTL for leaf angle at canopy-wide levels in maize

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

Dihydroartemisinin-loaded Magnetic Nanoparticles for Enhanced Chemodynamic Therapy

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.