Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death
M. E. Law, E. Yaaghubi, A. Ghilardi, B. J. Davis, R. B. Ferreira, J. Koh, S. Chen, S. F. DePeter, C. M. Schilson, C.-W. Chiang, C. D. Heldermon, P. Norgaard, R. K. Castellano, B. K. Law
This study identifies DDAs as inhibitors of AGR2 and ERp44, showing they induce DR4/5 oligomerization and cancer cell death via disrupting disulfide bonds.
bioRxiv · Jan 13, 2021Pharmacology & Toxicology