J. Koh

Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression

This study uses spatial transcriptomics to analyze cancer-associated fibroblasts in lung squamous cell carcinoma, linking their spatial organization to tumor progression and patient outcomes.

Unraveling the Complexity of Abdominal Aortic Aneurysm: Multiplexed Imaging Insights into C-Reactive Protein-Related Variations

This study uses multiplexed imaging to analyze immune and stromal cell changes in abdominal aortic aneurysms (AAAs) based on C-reactive protein (CRP) levels, revealing distinct immune cell distributions and macrophage phenotypes associated with CRP deposition.

Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana

This study shows that aliphatic aldoximes repress phenylpropanoid production and that altered methionine metabolism affects plant growth and development in Arabidopsis.

Mapping cell types in the tumor microenvironment from tissue images via deep learning trained by spatial transcriptomics of lung adenocarcinoma

The paper develops a deep learning method to map cell types in lung adenocarcinoma tumor microenvironments using H&E images trained on spatial transcriptomic data.

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

This study shows that de novo fatty-acid synthesis via ACC1 prevents iNKT cell death and promotes their pathogenic roles in allergic asthma.

Automated Hyperspectral Vegetation Index Derivation Using A Hyperparameter Optimization Framework for High-Throughput Plant Phenotyping

This paper introduces AutoVI, an automated system for generating trait-specific hyperspectral vegetation indices, which outperforms existing indices in estimating chlorophyll and sugar content in wheat.

Marked differences in local bone remodeling in response to different marrow stimulation techniques in a large animal

This study compares three marrow stimulation techniques in minipigs, finding that needle-puncture best preserves subchondral bone compared to drilling and microfracture.

Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death

This study identifies DDAs as inhibitors of AGR2 and ERp44, showing they induce DR4/5 oligomerization and cancer cell death via disrupting disulfide bonds.

Early growth response 2 (EGR2) is a novel regulator of the senescence program

This study identifies EGR2 as a novel regulator of senescence by activating the ARF and p16 promoters and reversing the senescent phenotype upon its ablation.

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.

This study shows that D-peptide crosslinked hydrogels induce adaptive immune responses that promote regenerative wound healing despite faster degradation.

Postnatal expansion, maturation and functionality of MR1 T cells in humans

This study examines the postnatal development of MR1-restricted T cells in humans, showing their expansion, maturation, and functional maturation in response to environmental exposure and tuberculosis infection.

Ribosomal stress-induced senescence as a novel pro-senescence strategy for p16 positive basal-like breast cancer

This study identifies ribosomal proteins as pro-senescence targets in p16 positive basal-like breast cancer, showing their role in inducing stable cell cycle arrest and poor prognosis.