S. Chen

Generative Neural Spike Prediction from Upstream Neural Activity via Behavioral Reinforcement

This paper develops a reinforcement learning framework to predict downstream neural spike trains from upstream activity using behavioral rewards, achieving better behavioral performance than existing methods.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Negatively charged α-Synuclein condensate modulates partitioning of molecules

This study shows that negatively charged α-Synuclein condensates influence molecular partitioning based on charge differences, revealing electrostatic effects on phase separation.

Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

This study identifies a microRNA cluster regulating sex-specific differences in metamorphosis by modulating hormonal and gene pathways in Drosophila.

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

This study uses cryo-ET to show that LRRK2 can form microtubule-bound filaments in its autoinhibited state, with structural differences compared to active-LRRK2 filaments.

A Mechanistic Understanding of the Activity-Stability Trade-off in PETase

This study investigates the activity-stability trade-off in PETase using simulations and experiments, revealing how reshaping loop dynamics can enhance both stability and activity.

PEX14 functions as a molecular link between optineurin and pexophagy in human cells

This study identifies PEX14 as a molecular link between optineurin and pexophagy, elucidating its role in recruiting autophagic machinery for peroxisome degradation.

The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice.

This study shows that gut microbiota depletion reduces cardiovascular inflammation in a mouse model of Kawasaki disease, and specific bacteria or their metabolites can alleviate vasculitis by improving gut barrier function.

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Human Breast Milk EVs Mitigate Endothelial Dysfunction: Preliminary Study

This study investigates the therapeutic potential of human breast milk EVs in mitigating endothelial dysfunction, showing reduced inflammation and improved vascular function in vitro and in mice.

A duplexed CRISPRi-based approach to predict synergistic antibiotic targets in Escherichia coli.

The paper uses CRISPRi to predict synergistic antibiotic targets in E. coli by testing gene co-repression and identifying novel interactions.

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases

This paper develops polymer-tethered fluorescent probes for tumor-associated protease imaging, showing improved signal and tumor-to-background ratios compared to small molecule probes.

Energy partitioning in the cell cortex

The paper measures energy partitioning between chemical and mechanical subsystems in the cell cortex and finds that energy distribution changes with Rho GTPase pathway manipulation.

Modifying Azithromycin to Mitigate Arrested Autophagy

This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Seeding competent TDP-43 persists in human patient and mouse muscle

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Development and application of GlycanDIA workflow for glycomic analysis

The paper develops GlycanDIA, a DIA-based workflow for glycan identification and quantification, showing improved sensitivity and the ability to detect low-abundant modified glycans.

Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.