DNA damage response signaling to mitochondria drives senescence
S. Yamauchi, Y. Sugiura, J. Yamaguchi, X. Zhou, T. Odawara, S. Fukaya, I. Naguro, Y. Uchiyama, H. Ichijo
This study identifies BNIP3 as a mediator of DNA damage response signaling to mitochondria, which promotes senescence by altering mitochondrial structure and metabolism to increase p16 expression.
bioRxiv · Sep 22, 2022Cell Biology