X. Zhou

Brain-specific Gata4 downregulation in Greywick female mice models the metabolic subtype of polycystic ovary syndrome

This study shows that Gata4 downregulation in the hypothalamus of Greywick female mice models the metabolic subtype of PCOS by affecting fertility and food intake genes.

Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

This study examines the evolution of the resistome in Salmonella Gallinarum during its transition to endemicity, revealing localized mobilome-driven resistance profiles.

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Convergent expansions of keystone gene families drive metabolic innovation in a major eukaryotic clade

The paper investigates the relationship between gene family expansions and metabolic traits in yeasts, finding that keystone gene families drive multiple metabolic innovations.

Specialization restricts the evolutionary paths available to yeast sugar transporters

The paper investigates how specialization in yeast sugar transporters restricts evolutionary paths by analyzing sequence-function relationships and evolutionary history.

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells

This study shows that heat-killed Lactobacillus johnsonii reduces herpesvirus-induced pulmonary fibrosis in HCT mice by increasing PD-L1 on dendritic cells, which suppresses Th17 cell IL-17A.

De novo synthesis of fatty acids in Archaea via an archaeal fatty acid synthase complex

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program

The paper examines microbiome and immune changes in depression during a psychosocial intervention, finding a protective role for Prevotella-dominant microbiomes and reduced inflammation.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Transcriptional reprogramming deploys a compartmentalized "timebomb" in Catharanthus roseus to fend off chewing herbivores

This study identifies a transcription factor that coordinates the production of insecticidal alkaloids in response to herbivory and cold stress in Catharanthus roseus.

Unveiling the PHR-centered regulatory network orchestrating the phosphate starvation signaling in Chinese fir (Cunninghamia lanceolata)

This study identifies ClPHRs as key regulators of phosphate starvation signaling in Chinese fir, revealing evolutionary differences in the SPX-PHR module compared to model plants.

Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage

The paper analyzes gene family evolution across nearly all known Saccharomycotina yeast species, finding distinct evolutionary patterns with gene loss linked to metabolic and genomic changes.

Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate type I interferon signaling and endothelial function.

This study identifies nuclear eNOS's role in modulating ADAR1 activity and type I interferon signaling, linking NO bioavailability to endothelial function and atherogenesis.

A noncanonical GTPase signaling mechanism controls exit from mitosis in budding yeast

This study reveals a noncanonical GTPase signaling mechanism in budding yeast where Tem1 localization, not its nucleotide state, controls MEN activation by increasing effective concentration for Cdc15 interaction.

CPT2 mediated fatty acid oxidation is dispensable for humoral immunity

This study shows that CPT2-mediated fatty acid oxidation is not essential for humoral immunity in mice, as CPT2 deficiency does not impair B cell development, activation, or antibody production.

Control of Inflammatory Response by Tissue Microenvironment

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.

Structural basis of the bacterial flagellar motor rotational switching

This study presents cryo-EM structures of the bacterial flagellar motor C ring in two rotational states, revealing the structural basis of directional switching.

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening

This study uses image registration to transform DTI-derived muscle architecture from an extended to a flexed position, showing no significant change in average architectural parameters.

The distribution of Apis laboriosa revisited: range extensions and biogeographic affinities

This paper revises the distribution of Apis laboriosa, extending its range and discussing biogeographic affinities and new localities.

Diffusion and Oligomerization States of the Muscarinic M1 Receptor in Live Cells - The Impact of Ligands and Membrane Disruptors

This study uses single-molecule techniques to analyze the diffusion and oligomerization of M1R in live cells, showing ligands and membrane disruptors modulate these states.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes

This study identifies ERG251 mutations that confer azole tolerance and pleiotropic effects on stress responses and filamentation in C. albicans.

Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

Thymidine Phosphorylase Promotes the Formation of Abdominal Aortic Aneurysm in Mice Fed a Western Diet

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.