Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors
M. C. Ludikhuize, S. Gevers, N. T. B. Nguyen, M. Meerlo, S. K. Shafiei Roudbari, M. C. Gulersonmez, E. C. A. Stigter, J. Drost, H. C. Clevers, B. M. Burgering, M. J. RodrIguez-Colman
This study shows that rewiring glucose metabolism enhances 5-FU efficacy in p53-deficient colorectal tumors by altering nucleotide pools without increasing toxicity in healthy cells.
bioRxiv · Nov 11, 2021Cancer Biology