Author

M. Meerlo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. M. T. Burgering· 2 shared M. C. Ludikhuize· 2 shared N. T. B. Nguyen· 2 shared B. M. Burgering· 1 shared E. C. A. Stigter· 1 shared E. C. Brombacher· 1 shared F. C. Durst· 1 shared G. Dunkel· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

B. M. T. Burgering

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors

M. C. Ludikhuize, S. Gevers, N. T. B. Nguyen, M. Meerlo, S. K. Shafiei Roudbari, M. C. Gulersonmez, E. C. A. Stigter, J. Drost, H. C. Clevers, B. M. Burgering, M. J. RodrIguez-Colman

This study shows that rewiring glucose metabolism enhances 5-FU efficacy in p53-deficient colorectal tumors by altering nucleotide pools without increasing toxicity in healthy cells.

bioRxiv · Nov 11, 2021Cancer Biology

Calpain-2 regulates hypoxia/HIF-induced amoeboid reprogramming and metastasis

V. te Boekhorst, L. Jiang, M. Mahlen, M. Meerlo, G. Dunkel, F. C. Durst, Y. Yang, H. Levine, B. M. T. Burgering, P. Friedl

This study identifies calpain-2 as a regulator of hypoxia-induced amoeboid reprogramming and metastasis in breast and head and neck cancers.

bioRxiv · Jan 6, 2020 · PreprintCancer Biology

Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis

M. C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julia, N. T. B. Nguyen, E. C. Brombacher, J.-H. Paik, B. M. T. Burgering, M. J. Rodriguez Colman

The paper shows that FOXO and Notch signaling regulate mitochondrial fission, driving intestinal stem cell differentiation into secretory lineages through metabolic rewiring.

bioRxiv · Sep 20, 2019Cell Biology