S. Hernando-Amado

A new type of AmpC β-lactamases defined by PIB-1, a metal-dependent carbapenem-hydrolyzing β-lactamase, from Pseudomonas aeruginosa: structural and functional analysis.

The paper identifies PIB-1, a metal-dependent carbapenem-hydrolyzing β-lactamase from Pseudomonas aeruginosa, structurally and functionally distinct from typical AmpC β-lactamases.

Efflux pump mutations in Pseudomonas aeruginosa cause low-level clinical resistance and high-level tolerance to antibiotics in patients

This study shows that mexZ mutations in Pseudomonas aeruginosa lead to antibiotic tolerance and altered colonization in human airway models through overexpression of lecA.

Evolution under low antibiotic concentrations: a risk for the selection of Pseudomonas aeruginosa multidrug resistant mutants in nature

This study identifies sub-MIC selective windows for seven antibiotics in Pseudomonas aeruginosa and shows that natural antibiotic concentrations can select multidrug-resistant mutants.

Novel inducers of the expression of multidrug efflux pumps that trigger Pseudomonas aeruginosa transient antibiotic resistance

This study identifies non-antibiotic compounds that induce multidrug efflux pumps in Pseudomonas aeruginosa, leading to transient antibiotic resistance.

Mutation-driven evolution of Pseudomonas aeruginosa in the presence of either ceftazidime or ceftazidime/avibactam

This study investigates mutation-driven resistance in Pseudomonas aeruginosa exposed to ceftazidime or ceftazidime/avibactam, identifying common genetic changes and their implications for antibiotic susceptibility.