J. L. Martinez

A new type of AmpC β-lactamases defined by PIB-1, a metal-dependent carbapenem-hydrolyzing β-lactamase, from Pseudomonas aeruginosa: structural and functional analysis.

The paper identifies PIB-1, a metal-dependent carbapenem-hydrolyzing β-lactamase from Pseudomonas aeruginosa, structurally and functionally distinct from typical AmpC β-lactamases.

Efflux pump mutations in Pseudomonas aeruginosa cause low-level clinical resistance and high-level tolerance to antibiotics in patients

This study shows that mexZ mutations in Pseudomonas aeruginosa lead to antibiotic tolerance and altered colonization in human airway models through overexpression of lecA.

Role of Lactate in the Regulation of Transcriptional Activity of Breast Cancer-Related Genes and Epithelial-to-Mesenchymal Transition Proteins: A Comparison of MCF7 and MDA-MB-231 Cancer Cell Lines

This study shows that endogenous lactate, not glucose, alters gene and protein expression in breast cancer cell lines, affecting carcinogenesis-related genes and EMT markers.

Host space, not energy or symbiont size, constrains feather mite abundance across passerine bird species

The paper investigates factors constraining feather mite abundance in passerine birds, finding host space rather than energy or symbiont size is the main constraint.

High-throughput screening of a Debaryomyces hansenii library for potential candidates with improved stress tolerance and wider carbon utilisation capabilities

This study screens D. hansenii strains for improved stress tolerance and carbon utilisation using high-throughput methods, finding enhanced performance under NaCl and pH 4 conditions.

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

Evolution under low antibiotic concentrations: a risk for the selection of Pseudomonas aeruginosa multidrug resistant mutants in nature

This study identifies sub-MIC selective windows for seven antibiotics in Pseudomonas aeruginosa and shows that natural antibiotic concentrations can select multidrug-resistant mutants.

A wide-ranging Pseudomonas aeruginosa PeptideAtlas build: a useful proteomic resource for a versatile pathogen.

The paper builds a comprehensive Pseudomonas aeruginosa PeptideAtlas with high proteome coverage, providing a valuable resource for proteomic studies of this pathogen.

The analysis of the role of MexAB-OprM on quorum sensing homeostasis shows that the apparent redundancy of Pseudomonas aeruginosa multidrug efflux pumps allows keeping the robustness and the plasticity of this intercellular signaling network

This study shows that overexpression of MexAB-OprM in Pseudomonas aeruginosa impairs quorum sensing by reducing intracellular octanoate, not by extruding the QS signal, highlighting the distinct mechanisms of efflux pump redundancy.

A Physiological Characterization in Controlled Bioreactors Reveals a Novel Survival Strategy for Debaryomyces hansenii at High Salinity and Confirms its Halophilic Behavior

This study characterizes Debaryomyces hansenii's physiology in controlled bioreactors, revealing its halophilic behavior and novel survival strategies at high salinity.

The inactivation of enzymes belonging to the central carbon metabolism, a novel mechanism of developing antibiotic resistance

This paper identifies a novel mechanism of antibiotic resistance in Stenotrophomonas maltophilia through the inactivation of central carbon metabolism enzymes, not through known resistance mechanisms like efflux or target modification.

Novel inducers of the expression of multidrug efflux pumps that trigger Pseudomonas aeruginosa transient antibiotic resistance

This study identifies non-antibiotic compounds that induce multidrug efflux pumps in Pseudomonas aeruginosa, leading to transient antibiotic resistance.

The guanine nucleotide exchange factor GBF1 participates in rotavirus replication

This study shows that GBF1 is required for rotavirus replication by facilitating VP7 and NSP4 processing and virion assembly.

Nanoscale organization of rotavirus replication machineries

This study uses super-resolution microscopy to reveal the nanoscale organization of rotavirus replication machineries, showing seven viral proteins and dsRNA arranged in six concentric layers within viro-plasms.

Mutation-driven evolution of Pseudomonas aeruginosa in the presence of either ceftazidime or ceftazidime/avibactam

This study investigates mutation-driven resistance in Pseudomonas aeruginosa exposed to ceftazidime or ceftazidime/avibactam, identifying common genetic changes and their implications for antibiotic susceptibility.

Biolog phenotype microarray: a tool for the identification of multidrug resistance efflux pumps inducers

This paper identifies inducers of two efflux pumps in Stenotrophomonas maltophilia using bioreporters and phenotype microarrays, showing inducers do not rely on efflux pumps for detoxification.

In-Depth Resistome Analysis by Targeted Metagenomics

The paper introduces ResCap, a targeted metagenomics platform for analyzing resistomes, enhancing sensitivity and specificity in detecting antimicrobial resistance genes.