IgG-aggregates rapidly up-regulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: A crucial role for FcgRI in the generation of reactive oxygen species.
S. Huot, C. Laflamme, P. R. Fortin, E. Boilard, M. Pouliot
This study shows that IgG-aggregates rapidly increase FcgRI expression on human neutrophils, mediated by FcgRIIa, and that FcgRI is essential for ROS production in response to immune complexes.
bioRxiv · Mar 4, 2020Immunology