Elastase-2 knockout mice display anxiogenic- and antidepressant-like phenotype: putative role for BDNF metabolism in prefrontal cortex
C. R. A. F. Diniz, C. Becari Ribeiro, A. Lesnikova, C. Biojone, M. C. O. Salgado, H. C. Salgado, L. B. M. Resstel, F. S. Guimaraes, E. Castren, P. Casarotto, S. Joca
This study shows that Elastase-2 knockout mice exhibit anxiogenic and antidepressant-like behaviors, possibly due to increased BDNF levels in the prefrontal cortex.
bioRxiv · Sep 12, 2017Animal Behavior & Cognition