Author

S. Ketharnathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Antony· 2 shared A. Braithwaite· 1 shared A. J. George· 1 shared A. Phipps-Green· 1 shared C. V. Chin· 1 shared G. Gimenez· 1 shared J. A. Horsfield· 1 shared J. Boocock· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

J. Antony

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2 papers

Recent·Most cited

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

C. V. Chin, J. Antony, S. Ketharnathan, G. Gimenez, K. M. Parsons, J. He, A. J. George, A. Braithwaite, P. Guilford, R. D. Hannan, J. A. Horsfield

The paper identifies GSK3 inhibitors as synthetic lethal with cohesin mutations, revealing Wnt pathway activation as a therapeutic target in cohesin mutant cancers.

bioRxiv · Jul 23, 2020Cancer Biology

A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression

S. Ketharnathan, M. Leask, J. Boocock, A. Phipps-Green, J. Antony, J. O'Sullivan, T. Merriman, J. Horsfield

This study identifies a genetic variant linked to serum urate levels and shows it enhances HNF4A-dependent PDZK1 expression, potentially increasing urate transport.

bioRxiv · Jul 8, 2018Cell Biology