Author

J. Antony

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

G. Gimenez· 2 shared J. Horsfield· 2 shared M. Clarke· 2 shared S. Ketharnathan· 2 shared A. Braithwaite· 1 shared A. J. George· 1 shared A. Kuo· 1 shared A. M. Newman· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

G. Gimenez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LMO2 is critical for early metastatic events in breast cancer

S. S. Sikandar, J. Antony, G. S. Gulati, A. Kuo, W. H. D. Ho, S. Das, C. B. Steen, T. A. Pereira, D. Qian, P. A. Beachy, F. Dirbas, K. Red-Horse, T. H. Rabbitts, J. P. Thiery, A. M. Newman, M. Clarke

The paper identifies LMO2-expressing tumor cells as metastasis-initiating cells and shows LMO2-STAT3 signaling promotes breast cancer metastasis.

bioRxiv · May 26, 2021 · PreprintCancer Biology

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

C. V. Chin, J. Antony, S. Ketharnathan, G. Gimenez, K. M. Parsons, J. He, A. J. George, A. Braithwaite, P. Guilford, R. D. Hannan, J. A. Horsfield

The paper identifies GSK3 inhibitors as synthetic lethal with cohesin mutations, revealing Wnt pathway activation as a therapeutic target in cohesin mutant cancers.

bioRxiv · Jul 23, 2020Cancer Biology

BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells.

J. Antony, G. Gimenez, T. Taylor, U. Khatoon, R. C. Day, I. M. Morison, J. Horsfield

This study shows that BET inhibition reduces aberrant RUNX1 and ERG transcription in STAG2 mutant leukemia cells by blocking enhancer-driven gene expression during differentiation.

bioRxiv · Sep 10, 2019Cancer Biology

A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression

S. Ketharnathan, M. Leask, J. Boocock, A. Phipps-Green, J. Antony, J. O'Sullivan, T. Merriman, J. Horsfield

This study identifies a genetic variant linked to serum urate levels and shows it enhances HNF4A-dependent PDZK1 expression, potentially increasing urate transport.

bioRxiv · Jul 8, 2018Cell Biology

Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation

M. Adorno, B. Nicolis di Robilant, S. Sikandar, V. Haro Acosta, J. Antony, C. Heller, M. Clarke

This study shows Usp16 modulates Wnt signaling in tissues by regulating Cdkn2a, affecting stem cell expansion and regeneration, and identifies therapeutic implications for diseases like Down Syndrome.

bioRxiv · Jun 8, 2018Cell Biology