Sequential Measurements of Catalytic Activities of Multi-Drug-Resistance Transporters and Cytochrome P450 Enzymes by Cytometry of Reaction Rate Constant
V. Koshkin, M. Bleker de Oliveria, S. Kochmann, C. Peng, S. N. Krylov
This study compares sequential measurements of MDR transporter and CYP enzyme activities using CRRC to determine if the order affects results, finding that MDR activity is significantly impacted by prior CYP measurement.
bioRxiv · Oct 15, 2020 · PreprintCancer Biology