C. Peng

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

Molecular Architecture of Monkeypox Mature Virus

This study uses cryo-ET and STA to reveal the architecture of mature MPXV particles and identifies irregular virions with distorted core walls.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

Molecular basis for the host range function of the poxvirus PKR inhibitor E3

This paper identifies species-specific interactions between poxvirus PKR inhibitors E3 and K3 and host PKR proteins, challenging the sequestration model for E3 function.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity

This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

This study shows that inhibiting HDAC10 increases SPARC expression, which suppresses melanoma growth and restores sensitivity to BRAF inhibitors.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

The ATP-exporting channel Pannexin-1 promotes CD8+ T cell effector and memory responses

This study shows that Pannexin-1 promotes CD8+ T cell effector and memory responses through distinct mechanisms involving eATP export and purinergic receptor activation.

Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3

This study determines the cryo-EM structure of human CaV2.3 channels and identifies key residues and interactions involved in channel gating and inactivation.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

Proteomics and Functional Analysis Revealed TaGSTU6/TaCBSX3 Enhances Wheat Resistance to Powdery Mildew

Proteomics identified differences in wheat resistance to Pst and Bgt, with TaGSTU6/TaCBSX3 interaction specifically enhancing resistance to Bgt.

Mod3D: A Low-Cost, Flexible Modular System of Live-Cell Microscopy Chambers and Holders

The paper introduces a low-cost, modular live-cell microscopy system using 3D printing to reduce plastic waste and costs compared to commercial chambers.

The cryo-EM structure of the chloroplast ClpP complex reveals an interaction with the co-chaperonin complex that inhibits ClpP proteolytic activity

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells

This study shows that P2RX7 expression in effector CD8+ T cells influences their differentiation into central and resident memory cells through transcriptional changes.

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

The paper compares the inhibition of PKR by K3 orthologs from different orthopoxviruses across 17 mammalian species, finding species-specific inhibition and highlighting the need for experimental validation over phylogenetic assumptions.

MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease

This study shows that recombinant MVA vaccines expressing modified S proteins inhibit SARS-CoV-2 replication and prevent lethal disease in transgenic mice.

Sequential Measurements of Catalytic Activities of Multi-Drug-Resistance Transporters and Cytochrome P450 Enzymes by Cytometry of Reaction Rate Constant

This study compares sequential measurements of MDR transporter and CYP enzyme activities using CRRC to determine if the order affects results, finding that MDR activity is significantly impacted by prior CYP measurement.

Multi-Drug-Resistance in Drug-Naive and Drug-Exposed Ovarian Cancer Cells Responds Differently to Cell Culture Dimensionality

The paper examines how cell clustering affects intrinsic and acquired multi-drug resistance in ovarian cancer cells using cytometry of reaction rate constants.