Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures
C. Verheul, I. Ntafoulis, T. Kers, Y. Hoogstrate, P. Mastroberardino, S. Barnhoorn, C. Payan, R. Tching Chi Yen, E. Struys, S. Koolen, C. Dirven, S. Leenstra, P. French, M. Lamfers
The paper establishes twelve patient-derived IDH1 mutant glioma cell cultures, confirms their similarity to parental tumors, and identifies nine FDA-approved drugs with activity against IDH-mutant gliomas.
bioRxiv · Apr 9, 2021 · PreprintCancer Biology