Author

P. French

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. van Royen· 2 shared A. Ray Chaudhuri· 1 shared A. Tomas· 1 shared B. Jones· 1 shared B. Valkenburg· 1 shared C. Dirven· 1 shared C. Dunsby· 1 shared C. Koyunlar· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

M. van Royen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures

C. Verheul, I. Ntafoulis, T. Kers, Y. Hoogstrate, P. Mastroberardino, S. Barnhoorn, C. Payan, R. Tching Chi Yen, E. Struys, S. Koolen, C. Dirven, S. Leenstra, P. French, M. Lamfers

The paper establishes twelve patient-derived IDH1 mutant glioma cell cultures, confirms their similarity to parental tumors, and identifies nine FDA-approved drugs with activity against IDH-mutant gliomas.

bioRxiv · Apr 9, 2021 · PreprintCancer Biology

SMARCAD1 Mediated Active Replication Fork Stability Maintains Genome Integrity

C. Lo, M. van Toorn, V. Gaggioli, M. Paes Dias, Y. Zhu, E. Maria Manolika, W. Zhao, M. van der Does, C. Mukherjee, J. Souto Goncalves, M. van Royen, P. French, J. Demmers, I. Smal, H. Lans, , N. Taneja

This study identifies SMARCAD1 as a critical factor for replication fork stability, showing its role in preventing genome instability and enhancing resistance to replication poisons.

bioRxiv · Oct 5, 2020Cell Biology

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists

Z. Fang, S. Chen, P. Pickford, J. Broichhagen, D. Hodson, I. R. Correa, S. Kumar, F. Gorlitz, C. Dunsby, P. French, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. Jones

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.

bioRxiv · Feb 24, 2020Pharmacology & Toxicology

Effective Tyrosine Kinase Inhibitors result in the intracellular accumulation of EGFR and allows response prediction in patients

M. de Wit, Y. Gao, D. Mercieca, I. de Heer, B. Valkenburg, M. van Royen, J. Aerts, P. Sillevis Smitt, P. French

The paper shows that EGFR tyrosine kinase inhibitors (TKIs) cause intracellular EGFR accumulation only in specific mutation-TKI combinations, which predicts clinical response in patients.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology

Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish

E. Gioacchino, C. Koyunlar, H. de Looper, M. de Jong, T. Dobrzycki, R. Hoogenboezem, J. Zink, D. Bosch, P. van Strien, M. E. van Royen, P. French, E. Bindels, R. Monteiro, K. J. Gussinklo, I. P. Touw, E. de Pater

This study identifies Gata2b's role in myeloid-lymphoid lineage decisions in zebrafish using single-cell transcriptomics.

bioRxiv · Sep 4, 2019 · PreprintImmunology