Author

Y. Hoogstrate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. de Heer· 3 shared M. Sanson· 3 shared T. Gorlia· 3 shared V. Golfinopoulos· 3 shared W. Wick· 3 shared C. M. S. Tesileanu· 2 shared E. Franceschi· 2 shared J. M. Kros· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

I. de Heer

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Author profile →

4 papers

Recent·Most cited

Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma

S. A. Ghisai, L. van Hijfte, W. R. Vallentgoed, C. M. S. Tesileanu, I. de Heer, J. M. Kros, M. Sanson, T. Gorlia, W. Wick, M. A. Vogelbaum, A. A. Brandes, E. Franceschi, P. M. Clement, A. K. Nowak, V. Golfinopoulos, , Y. Hoogstrate

This study identifies DNA-methylation and RNA-expression signatures that improve grading of IDH-mutant astrocytomas beyond current methods.

bioRxiv · Mar 19, 2024Cancer Biology

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

W. R. Vallentgoed, Y. Hoogstrate, K. A. van Garderen, L. van Hijfte, E. van Dijk, M. C. Kouwenhoven, J. M. Niers, K. Draaisma, I. Martin, W. W. de Leng, C. M. S. Tesileanu, I. de Heer, M. Diepeveen, A. Lavrova, P. P. Eijk, , P. J. French

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

bioRxiv · Mar 5, 2024Cancer Biology

Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures

C. Verheul, I. Ntafoulis, T. Kers, Y. Hoogstrate, P. Mastroberardino, S. Barnhoorn, C. Payan, R. Tching Chi Yen, E. Struys, S. Koolen, C. Dirven, S. Leenstra, P. French, M. Lamfers

The paper establishes twelve patient-derived IDH1 mutant glioma cell cultures, confirms their similarity to parental tumors, and identifies nine FDA-approved drugs with activity against IDH-mutant gliomas.

bioRxiv · Apr 9, 2021 · PreprintCancer Biology

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

M. Tesileanu, W. Vallentgoed, M. Sanson, W. Taal, P. Clement, W. Wick, A. Brandes, J.-F. Baurain, O. Chinot, H. Wheeler, S. Gill, M. Griffin, L. Rogers, R. Ruda, M. Weller, , van den Bent

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

bioRxiv · Dec 10, 2020 · PreprintCancer Biology