Unprotected Peptide Macrocyclization and Stapling via A Fluorine-Thiol Displacement Reaction
M. S. Islam, S. L. Junod, S. Zhang, Z. Y. Buuh, Y. Guan, K. H. Kaneria, Z. Lyu, V. Voelz, W. Yang, R. E. Wang
This paper introduces a new peptide stapling method using fluorine-thiol displacement reaction, showing improved stability, affinity, and cell permeability compared to traditional methods.
bioRxiv · Sep 9, 2020Cell Biology