S. Zhang

Chronic nicotine reduces nigral dopaminergic activity and remodels pedunculopontine cholinergic subpopulations

This study examines how chronic nicotine affects dopaminergic neurons in the substantia nigra and cholinergic neurons in the pedunculopontine nucleus, revealing changes in their activity and morphology that may contribute to Parkinson's disease resilience.

Mutations and structural variants arising during double-strand break repair

The paper studies mutations and structural variants during double-strand break repair in budding yeast, finding that repair-associated deletions and template switches depend on microhomology and homeology.

De novo design of light-regulated dynamic proteins using deep learning

This paper designs light-regulated dynamic proteins using deep learning, showing precise optogenetic control of cellular processes.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Unbiased preclinical phenotyping reveals neuroprotective properties of pioglitazone

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

This paper uses molecular dynamics simulations to compare how RY785 and TEA inhibit Kv2.1 channels, showing RY785 stabilizes a semi-open gate state while TEA blocks the pore.

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

Confidence-Enhanced Semi-supervised Learning for Mediastinal Neoplasm Segmentation

This paper introduces a confidence-enhanced semi-supervised learning framework for mediastinal neoplasm segmentation, improving performance by leveraging unlabeled data and refining prediction reliability.

Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

This study identifies physical interactions between septins and the exocyst complex in fission yeast, showing septins guide exocyst localization for proper cytokinesis.

A detailed analysis of 16S rRNA gene sequencing and conventional PCR-based testing for the diagnosis of bacterial pathogens and discovery of novel bacteria

This study compares 16S rRNA gene sequencing and conventional PCR for diagnosing bacterial pathogens in chickens with swollen head syndrome, finding that sequencing is more reliable and can detect novel bacteria.

Lipidic and senescent macrophages predict progression and response to combinatorial immunotherapy in triple-negative breast cancer

A Multitrait Genome-Wide Association Study Reveals a Requirement for the Strigolactone Receptor DWARF14 in Optimal GOLVEN10 Signaling

This study identifies a genetic link between strigolactone signaling and GLV10 responsiveness in Medicago truncatula through genome-wide association and mutant analysis.

O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool

This paper identifies and predicts O-glycosylated RNA using a chemoenzymatic method and a computational tool, revealing their role in pancreatic cancer progression.

Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus

This study investigates how black phosphorus nanosheets induce a viable but non-culturable state in Bacillus tropicus, revealing suppressed metabolism and respiratory pathways as key mechanisms.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers

This study develops a durable antimicrobial surface (DAMS) using 3D-printed microstructures and ZnO nanoflowers, showing over 90% bacterial reduction after 12 hours and effectiveness after abrasion.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

This study shows that Gγ13 signaling in tuft cells is essential for resolving lung inflammation and promoting recovery after severe injury.

Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

This study identifies S-HsfA2 in Arabidopsis as a factor that prevents hyperactivation of the heat stress response, balancing heat resistance and growth.

Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

This study uses snRNA-seq in pigs to reveal CLAs promote fat infiltration by altering myofiber types and adipocyte differentiation through JNK pathway inhibition.

Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse Caenorhabditis elegans strains

The paper assesses PFAS toxicity across genetically diverse C. elegans strains, finding genetic variation influences susceptibility to specific PFAS structures.

Massively parallel free energy calculations for in silico affinity maturation of designed miniproteins

This study uses free energy calculations to predict affinity maturation of miniproteins, finding that simulation methods can classify mutations but are less accurate than Flex ddG Rosetta.

Highly accurate metagenome-assembled genomes from human gut microbiota using long-read assembly, binning, and consolidation methods

This study improves metagenome-assembled genomes from human gut microbiota using long-read sequencing and novel assembly methods, yielding more high-quality MAGs and uncovering uncultured diversity.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

A Fast and Low-Cost Approach for Binding Mode Validation of AI-Designed Therapeutics

The paper introduces HDX FineMapping, a method that achieves full sequence coverage and epitope characterization for AI-designed therapeutics without requiring mutations or crystallization.

PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer

This study develops PSMA-guided PROTACs for prostate cancer, showing they selectively degrade target proteins in PSMA-overexpressing cells and improve therapeutic effects in vivo.

Impacts of global warming on fertility of male fishes: evidence from meta-analysis of temperature effects on spermatozoa motility

This study uses a meta-analysis of 20 fish species to show that increased water temperature reduces sperm motility and related parameters in cold-water species more than in warm-water species.