Y. Guan

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

Pseudomonas taxonomic and functional microdiversity in the wheat rhizosphere is cultivar-dependent and links to disease resistance profile and root diameter

The paper examines cultivar-dependent Pseudomonas microdiversity in wheat rhizosphere, linking it to disease resistance and root diameter.

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

This study shows TRIP13 localizes to synapsed chromosomes and is a dosage-sensitive regulator of meiosis, with loss leading to sterility and meiotic defects.

Quantitative Profiling of Lysosomal pH Heterogeneity using Fluorescence Lifetime Imaging Microscopy

This paper introduces a FLIM-based method to quantitatively analyze lysosomal pH heterogeneity in mammalian cells and C. elegans, revealing pH differences and dynamics without transgenic reporters.

The potential of Pseudomonas fluorescens SBW25 to produce viscosin enhances wheat root colonization and shapes root-associated microbial communities in a plant genotype dependent manner in soil systems

This study shows that Pseudomonas fluorescens SBW25 produces viscosin, enhancing wheat root colonization and altering microbial communities in a plant genotype-dependent manner in soil.

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

This study identifies MIP-1 and MIP-2 as C. elegans germ granule proteins that recruit Vasa homolog GLH-1 and are essential for granule formation and germ line development.

Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

This study shows sustained oxygenation improves diabetic wound healing by enhancing epithelialization, angiogenesis, and reducing inflammation without drugs.

An integrated strategy reveals complex glycosylation of erythropoietin using top-down and bottom-up mass spectrometry

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

Unprotected Peptide Macrocyclization and Stapling via A Fluorine-Thiol Displacement Reaction

This paper introduces a new peptide stapling method using fluorine-thiol displacement reaction, showing improved stability, affinity, and cell permeability compared to traditional methods.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China

The paper identifies 2019-nCoV related coronaviruses in Malayan pangolins, suggesting they may be intermediate hosts for the virus.

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 As Marker of Aggressive Disease

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

High throughput single cell sequencing of both T-cell-receptor-beta alleles

The paper develops a high-throughput method to analyze both T-cell-receptor-beta alleles in single cells using Next Generation Sequencing.

The Association between Alcohol Consumption and Telomere Length: A Meta-Analysis Focusing on Observational Studies

This paper conducts a meta-analysis of observational studies to assess the association between alcohol consumption and telomere length, finding a significant link with variability across study types and populations.

RNA-Seq analysis of compatible and incompatible styles of Pyrus species at the beginning of pollination

The paper compares gene expression in compatible and incompatible pollination styles of Pyrus species, identifying pathways and genes involved in self-incompatibility.