Nanoconfinement of Microvilli Alters Gene Expression and Boosts T cell Activation
M. Aramesh, D. Stoycheva, I. Sandu, S. J. Ihle, T. Zund, J.-Y. Shiu, C. Forro, M. Asghari, M. Bernero, S. Lickert, A. Oxenius, V. Vogel, E. Klotzsch
This study shows that nanoporous surfaces enhance T cell activation by altering gene expression and promoting microvilli formation through size-dependent protein segregation.
bioRxiv · Apr 19, 2021Bioengineering