O. Medalia

This study investigates the delayed localization of A-type lamins to nuclear envelope rupture sites in HGPS, identifying farnesylation and proteolytic cleavage as key factors affecting this process.

This study determines the 3D structure of vimentin intermediate filaments, revealing how disordered domains contribute to their mechanical properties.

The paper shows that keratin isoform shifts during wound healing modulate motility signals by activating myosin motors through isoform-specific interactions with vimentin shuttling kinases.

The paper uses cryo-EM to analyze microbial cellular architecture and finds that structural similarity correlates with taxonomic distance within families but not above.

This study uses cryo-ET to reveal three distinct actin sub-domains in lamellipodia, including filaments with barbed ends pointing toward the cell center.

This study identifies an allosteric network in vinculin regulated by talin, showing how force and binding dynamics control focal adhesion formation.

This study identifies myosin-X and DAAM1 as key factors promoting chiral growth in adherent filopodia, revealing how actin dynamics drive left-right asymmetry in cellular protrusions.

This study identifies Brl1's amphipathic helix as essential for NE fusion during NPC biogenesis in yeast.

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

This study determines the cryo-EM structure of the oxytocin receptor bound to oxytocin, revealing its activation mechanism and ligand recognition.

The paper shows lamin C, BAF, and cGAS accumulate at nuclear envelope rupture sites in mouse cells, with lamin A/C involvement in DNA sensing.

This study reveals the subnanometer structure of vimentin filaments in mouse cells, showing their helical symmetry and molecular composition.

This study uses cryo-electron microscopy to reveal the structural heterogeneity of keratin 5/keratin 14 filaments, showing variations in diameter and subunit organization.

This study develops a method to determine actin filament polarity in cryo-tomograms and shows a linear relationship between actin polarity and distance from the apical boundary in focal adhesions.

This study reveals the in-situ organization of cellulosomes and their substrates during microbial fiber degradation, showing phenotypic heterogeneity and growth-phase dependent dynamics.

This study examines a lamin A/C mutation in mice, revealing structural changes in nuclear filaments and chromatin organization linked to striated muscle disease.

The paper analyzes lamin isoform interactions with nuclear pore complexes using microscopy data from mouse fibroblasts, showing their role in maintaining nuclear envelope organization.

The paper measures the mechanical properties of lamin filaments in their native meshwork using multiple techniques and finds they exhibit non-Hookean behavior and small-world network topology.

The paper develops a morphometric screen to analyze platelet cytoskeletal organization and identifies integrin αIIbβ3-specific contractile phenotypes in response to matrix stiffness and inhibitors.

This study investigates how vinculin's conformational changes affect focal adhesion properties by analyzing the transition from closed to open states.