This study tracks the genetic pathways of high-level azithromycin resistance in Neisseria gonorrhoeae through experimental evolution and whole genome sequencing.

bioRxiv · Dec 2, 2020Microbiology

Streptococcus pneumoniae serotypes carried by young children and their association with Acute Otitis Media during the period 2016 - 2019.

E. Ekinci, S. Desmet, L. Van Heirstraeten, C. Mertens, I. Wouters, P. Beutels, J. Verhaegen, S. Malhotra-Kumar, H. Theeten, T. Npcarriage Study Group

This study examines pneumococcal serotypes in young children with and without acute otitis media, finding some serotypes are more common in AOM and not covered by current vaccines.

bioRxiv · Nov 16, 2020Immunology

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

R. Wheatley, J. Diaz Caballero, N. Kapel, A. Quinn, E. del Barrio-Tofino, C. Lopez-Causape, J. Hedge, G. Torrens, T. Van der Schalk, B. Britto Xavier, F. Fernandez-Cuenca, A. Arenzana, C. Recanatini, L. Timbermont, F. Sifakis, , C. MacLean

The paper tracks the rapid evolution of carbapenem resistance in P. aeruginosa during an acute infection, showing resistance rise and fall due to antibiotic treatment.

bioRxiv · Aug 10, 2020Evolutionary Biology

Comparison of biofilm dispersal approaches in Pseudomonas aeruginosa and evaluation of dispersed cells in acute infection mouse model

R. Ruhal, F. De Winter, B. de Jonger, B. B. Xavier, C. Lammens, H. Goossens, S. Kumar Singh, S. Malhotra-Kumar

This study compares biofilm dispersal methods in Pseudomonas aeruginosa and evaluates their ability to cause acute infections in mice, finding that efficient dispersal methods increase mortality.

bioRxiv · Jul 10, 2019 · PreprintMicrobiology