A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy
B. D. Khalil, R. Sanchez, T. Rahman, C. A. Rodriguez-Tirado, S. Moritsch, A. Rodriguez Martinez, B. Miles, E. Farias, M. Mezei, J. F. Cheung, A. R. Nobre, N. Kale, K. C. Sproll, M. S. Sosa, J. A. Aguirre-Ghiso
This study identifies a novel NR2F1 agonist, C26, that suppresses metastasis by inducing cancer cell dormancy through NR2F1 activation in HNSCC.
bioRxiv · Jan 30, 2021Cancer Biology