T. Rahman

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

Chromium/cadmium plays a pivotal role to emerge amoxicillin resistant Staphylococcus aureus

This study shows that chromium and cadmium exposure with low-dose amoxicillin increases amoxicillin resistance in Staphylococcus aureus by upregulating efflux pumps.

The ASC Speck And NLRP3 Inflammasome Function Are Spatially And Temporally Distinct

This study shows the NLRP3:ASC speck is not the NLRP3 inflammasome but a structure that amplifies its response by facilitating caspase-1 activation.

Correlation analysis of target selectivity and side effects of FDA-approved kinase inhibitors

The paper analyzes the correlation between target engagement and side effects of 18 FDA-approved kinase inhibitors to understand off-target effects and toxicity.

Regression QSAR Models for Predicting HIV-1 Integrase Inhibitors

This study develops two regression QSAR models using boosted Random Forest and K* algorithms to predict INSTI activity and identifies potential drug candidates from DrugBank.

A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy

This study identifies a novel NR2F1 agonist, C26, that suppresses metastasis by inducing cancer cell dormancy through NR2F1 activation in HNSCC.

Pathological turret mutations in the cardiac sodium channel cause long-range pore disruption

The paper investigates how turret mutations in Nav1.5 disrupt the sodium channel's structure and function, affecting ion permeability and causing cardiopathologies.

Proposed model of the Dictyostelium cAMP receptors bound to cAMP

The paper presents homology models of cAMP receptors from Dictyostelium discoideum, highlighting structural features that may explain differential cAMP binding affinities and activation mechanisms.

In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3

The paper identifies guanabenz and sephin1 as new allosteric modulators of ASIC3 through in silico screening of FDA-approved drugs and electrophysiological validation.

Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in the elongation factor-encoding gene, fusA1.

This study identifies a fusA1 mutation in Pseudomonas aeruginosa that increases antibiotic resistance and alters virulence gene expression through dysregulation of multiple pathways.

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.