BRK Phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG and metastatic potential.
S. Miah, C. Banks, Y. Ogunbolude, E. Bagu, J. MacAusland-Berg, A. Saraf, G. Hattem, C. Kempf, M. Sardiu, S. Napper, L. Florens, K. E. Lukong, M. P. Washburn
This study shows BRK phosphorylates SMAD4, leading to its proteasomal degradation and inhibition of the tumor suppressor FRK, which promotes metastasis.
bioRxiv · Dec 7, 2018Cancer Biology