Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progestins and Spironolactone
Y. Katsu, S. Kohno, K. Oka, X. Lin, S. Otake, N. E. Pillai, W. Takagi, S. Hyodo, B. Venkatesh, M. E. Baker
The paper analyzes the activation of elephant shark mineralocorticoid receptor by corticosteroids and progesterone, finding that aldosterone is absent in cartilaginous fishes and progesterone activates shark MR but not human MR.
bioRxiv · Dec 6, 2018Evolutionary Biology