X. Lin

Dynamic regulation of H2A.Zub and H3K27me3 by ambient temperature in plant cell fate determination

The paper shows that low temperature restores developmental defects in PRC2 mutants by promoting H2A.Zub deposition at embryonic genes, compensating for H3K27me3 loss and silencing these genes for post-germination development.

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Cathartocytosis: Jettisoning of Unwanted Material during Cellular Reprogramming

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

The paper introduces IDEA, a model that predicts DNA recognition sites and binding affinities using structure-sequence optimization, enabling physicochemical interpretation of protein-DNA interactions.

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites

This study shows that XRCC1 facilitates PARP1-mediated recruitment of PARP2 to DNA damage sites through PAR binding and interaction with PARP2.

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Sediment-associated processes account for most of the spatial variation in stream ecosystem respiration in the Yakima River basin

The paper evaluates a process-based model for predicting stream ecosystem respiration (ERtot) in the Yakima River basin and finds it fails to explain spatial variation, highlighting the importance of sediment-associated respiration and other factors.

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

A hemagglutinin and neuraminidase biased immunological memory shapes the dynamics of antibody responses to Influenza A virus

The paper shows that pre-existing immunity to specific influenza antigens biases post-infection antibody responses, altering their dynamics and breadth.

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's Disease

The paper studies sleep-wake abnormalities in a new PD mouse model and finds they mirror human PD symptoms, suggesting potential for understanding and treating sleep disruptions in PD.

FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection

This study identifies FABP4 as a host target that modulates SARS-CoV-2 infection, showing that its inhibition reduces viral replication and lung damage in infected hamsters.

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

PUPpy: a primer design pipeline for substrain-level microbial detection and absolute quantification.

PUPpy designs taxon-specific primers for substrain-level microbial detection and absolute quantification, outperforming 16S rRNA and shotgun sequencing in defined communities.

Reversibly-bonded Microfluidic Devices for Stable Cell Culture and Rapid, Gentle Cell Extraction

This paper introduces a reversible PDMS-PS bonding technique for microfluidic devices, enabling stable cell culture and gentle live cell extraction for downstream applications.

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

An automated archival single-nucleus total RNA sequencing platform mapping integrative and retrospective cell atlas of gliomas

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.