Author

S. Pascarelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

G.-i. Uechi· 2 shared P. Laurino· 2 shared B. Cellini· 1 shared C. Costantini· 1 shared D. Chiasserini· 1 shared G. Giardina· 1 shared M. Dindo· 1 shared S. Grottelli· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersEvolutionary Biology

G.-i. Uechi

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2 papers

Recent·Most cited

Insertions and deletions mediated functional divergence of Rossmann fold enzymes

S. Toledo-Patino, S. Pascarelli, G.-i. Uechi, P. Laurino

The paper identifies how insertions and deletions in Rossmann fold enzymes drove coenzyme specificity shifts from NAD(P) to SAM, revealing evolutionary mechanisms for functional divergence.

bioRxiv · May 16, 2022Evolutionary Biology

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics

M. Dindo, S. Pascarelli, D. Chiasserini, S. Grottelli, C. Costantini, G.-I. Uechi, G. Giardina, P. Laurino, B. Cellini

The paper investigates how genetic variations in AGT1 affect its conformational flexibility and fitness, revealing cryptic functions related to protein-protein interactions.

bioRxiv · May 24, 2021 · PreprintBiochemistry