Author

G.-I. Uechi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

P. Laurino· 3 shared S. Pascarelli· 2 shared B. Cellini· 1 shared B. E. Clifton· 1 shared C. Costantini· 1 shared D. Chiasserini· 1 shared G. Giardina· 1 shared M. A. Fariz· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

P. Laurino

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Insertions and deletions mediated functional divergence of Rossmann fold enzymes

S. Toledo-Patino, S. Pascarelli, G.-i. Uechi, P. Laurino

The paper identifies how insertions and deletions in Rossmann fold enzymes drove coenzyme specificity shifts from NAD(P) to SAM, revealing evolutionary mechanisms for functional divergence.

bioRxiv · May 16, 2022Evolutionary Biology

Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation

B. E. Clifton, M. A. Fariz, G.-I. Uechi, P. Laurino

This study uses experimental evolution to show that loss of the tRNA modification m1G37 in E. coli is tolerated via compensatory mutations in the proline-tRNA ligase gene proS, revealing ProRS as a gatekeeper of translational accuracy.

Nucleic Acids Research · Nov 11, 2021Peer-reviewedBiochemistry

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics

M. Dindo, S. Pascarelli, D. Chiasserini, S. Grottelli, C. Costantini, G.-I. Uechi, G. Giardina, P. Laurino, B. Cellini

The paper investigates how genetic variations in AGT1 affect its conformational flexibility and fitness, revealing cryptic functions related to protein-protein interactions.

bioRxiv · May 24, 2021 · PreprintBiochemistry