Epigenetic regulator BMI1 promotes fusion-positive rhabdomyosarcoma proliferation and constitutes a novel therapeutic target
C. E. Shields, S. Potlapalli, S. M. Cuya-Smith, S. K. Chappell, D. Chen, D. Martinez, J. Pogoriler, K. S. Rathi, S. A. Patel, J. M. Maris, R. W. Schnepp
This study shows BMI1 promotes FP-RMS proliferation and its inhibition reduces tumor growth and activates the Hippo pathway.
bioRxiv · Apr 18, 2020Cancer Biology