J. M. Maris

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

This paper describes a collaborative model between young investigators and cancer advocates to enhance pediatric cancer research through improved communication and team science.

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

The paper investigates OMAS in neuroblastoma, finding polyclonal B- and T-cell infiltration and TLS enrichment, linking them to autoimmune and anti-tumor responses.

This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.

The paper shows that epigenetic states in neuroblastoma cells determine their response to inflammatory stimuli, with mesenchymal states being more responsive than adrenergic states.

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

This study shows BMI1 promotes FP-RMS proliferation and its inhibition reduces tumor growth and activates the Hippo pathway.

This paper proposes a SARS-CoV-2 vaccination strategy targeting conserved viral regions and MHC-presented epitopes to induce broad immunity.

This study identifies LIN28B's role in promoting neuroblastoma metastasis through the regulation of PBK, a kinase that enhances self-renewal and migration.

The paper introduces a method to produce pMHC-I tetramer libraries using TAPBPR chaperone-mediated peptide exchange, enabling high-throughput analysis of TCR repertoires and pMHC-I specificities.