miR-495-3p Sensitizes BCR::ABL1 Expressing Leukemic cells to Tyrosine Kinase Inhibitors by Targeting Multidrug Resistance 1 Gene including in T315I Mutated cells
Y. Rittavee, J. Artus, C. Desterke, I. Simanic, L. Eduardo Botelho de Souza, S. Riccaldi, S. Coignard, Y. Ijjeh, P. Hugues, A. Bennaceur Griscelli, A. G. Turhan, A. Foudi
This study shows miR-495-3p reduces CML cell growth and TKI resistance by targeting MDR1, especially in T315I-mutant cells, and identifies it as a potential therapeutic target.
Experimental Hematology · Feb 1, 2023Peer-reviewedCancer Biology