Author

C. Desterke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:bulk RNA-seq· 7 Organism:human· 7 Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. G. Turhan· 5 shared A. Bennaceur Griscelli· 3 shared A. Bennaceur-Griscelli· 3 shared A. Foudi· 3 shared A. Hamai· 2 shared A. TURHAN· 2 shared F. Griscelli· 2 shared I. Simanic· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCancer Biology

A. G. Turhan

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Author profile →

10 papers

Recent·Most cited

Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) using patient-derived induced pluripotent stem cells (iPSC)

G. Telliam, C. Desterke, J. Imeri, R. Mkacher, N. Oudrhiri, E. Balducci, M. Arnoux, H. Acloque, A. Bennaceur-Griscelli, A. G. Turhan

This study uses patient-derived iPSCs with in vitro mutagenesis to model genomic instability in CML, identifying aberrations linked to blast crisis progression.

Cancers · May 3, 2023Peer-reviewedCancer Biology

mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

E. Cosialls, E. Pacreau, S. Ceccacci, R. Elhage, C. Duruel, C. Desterke, K. Roger, C. Guerrera, R. Ducloux, S. Souquere, G. Pierron, I. Nemazanyy, M. Kelly, E. Dalmas, Y. Chang, , A. Hamai

The paper shows that mTOR inhibition reduces Salinomycin-induced ferroptosis in breast cancer stem cells by modulating iron flux and mitochondrial function.

bioRxiv · May 2, 2023Cancer Biology

BCR-ABL promotes hematopoietic stem and progenitor cell formation in embryonic stem cells

J. Artus, A. Zenych, I. Simanic, C. Desterke, D. Clay, S. Saim, Y. Ijjeh, L. E. B. de Souza, S. Coignard, A. Bennaceur-Griscelli, A. G. Turhan, A. Foudi

This study shows that BCR-ABL expression in murine ESCs promotes the formation and maintenance of hematopoietic progenitors with a molecular signature similar to wild-type HSCs.

bioRxiv · Feb 3, 2023Cancer Biology

miR-495-3p Sensitizes BCR::ABL1 Expressing Leukemic cells to Tyrosine Kinase Inhibitors by Targeting Multidrug Resistance 1 Gene including in T315I Mutated cells

Y. Rittavee, J. Artus, C. Desterke, I. Simanic, L. Eduardo Botelho de Souza, S. Riccaldi, S. Coignard, Y. Ijjeh, P. Hugues, A. Bennaceur Griscelli, A. G. Turhan, A. Foudi

This study shows miR-495-3p reduces CML cell growth and TKI resistance by targeting MDR1, especially in T315I-mutant cells, and identifies it as a potential therapeutic target.

Experimental Hematology · Feb 1, 2023Peer-reviewedCancer Biology

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

Y. Chang, J. Mata-Garrido, C. desterke, E. Batsche, A. Hamai, S. Youssouf, D. Skurnik, A. Jalil, J.-C. Beche, E. Piaggio, L. Arbibe, Y. C. Marchand

This study identifies HP1γ as an epigenetic repressor of IFN-γ responsive genes at the gut epithelial barrier, showing its role in dampening immune responses.

bioRxiv · Dec 27, 2022 · PreprintImmunology

NR0B2 regulation during Primary Sclerosing Cholangitis defines a metabolic and pre-malignant reprogramming of Cholangiocyte

C. Desterke, C. Feray

The paper identifies NR0B2 deregulation in PSC liver and its role in metabolic and pre-malignant reprogramming of cholangiocytes through multi-omics analysis and single-cell transcriptomics.

bioRxiv · Sep 6, 2021 · PreprintPathology

ENOX2 NADH Oxidase: A BCR-ABL1-dependent cell surface and secreted redox protein in chronic myeloid leukemia (CML)

S. Baykal Kose, M. Voldoire, C. Desterke, N. Sorel, E. Cayssials, H. Johnson-Ansah, A. Guerci-Bresler, A. Bennaceur-Griscelli, J. C. Chomel, A. G. Turhan

This study identifies ENOX2 as a BCR-ABL1-dependent secreted redox protein upregulated in CML, with increased expression in patient plasma and cell lines.

bioRxiv · Jan 23, 2021Cancer Biology

Pharmacologically modified pluripotent stem cell-based cancer vaccines with anti-metastatic potential

M. Heront-Kishi, A. Asgorava, C. Desterke, D. Chaker, M. G. de Goer, A. TURHAN, A. Bennaceur, F. Griscelli

This study shows that combining pluripotent stem cells with a histone deacetylase inhibitor can create an effective cancer vaccine that targets cancer stem cells and reduces metastasis in breast cancer.

bioRxiv · May 27, 2020 · PreprintCancer Biology

Evidence of massive leukemic progenitor expansion in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML)

A. Turhan, P. Hugues, N. Sorel, C. Desterke, J. H. Bourhis, A. Bennaceur Griscelli, J. C. Chomel

The paper shows that leukemic progenitor expansion occurs in peripheral blood before cytological changes in CML patients after TKI discontinuation.

bioRxiv · Oct 22, 2019Cancer Biology

iPSC-derived Cancer Organoids Recapitulate Genomic and Phenotypic Alterations of c-met-mutated Hereditary Kidney Cancer

J. W. Hwang, C. Desterke, O. Feraud, S. Richard, S. Ferlicot, V. Verkarre, J. J. Patard, J. Loisel-Duwattez, A. Foudi, F. Griscelli, A. Bennaceur Griscelli, A. G. Turhan

The paper generates c-met-mutated iPSC-derived kidney organoids that recapitulate genomic and phenotypic features of PRCC, identifying common genes and validating their expression in both organoids and patient tumors.

bioRxiv · Jan 11, 2019 · PreprintCancer Biology