Author

S. Ruthstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:electronic health records· 1

Frequent Co-Authors

A. Meir· 2 shared F. Schwerdtfeger· 2 shared L. Gevorkyan-Airapetov· 2 shared A. Gruzman· 1 shared A. Magistrato· 1 shared A. Munder· 1 shared G. Walke· 1 shared J. Aupic· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. Meir

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4 papers

Recent·Most cited

An in cell site-specific labeling methodology reveals conformational changes of proteins in bacteria

Y. Shenberger, L. Gevorkyan-Airapetov, M. Hirsch, L. Hofmann, S. Ruthstein

This paper introduces an in-cell spin-labeling method for studying protein conformational changes in bacteria, enabling analysis of any protein size and cellular system.

bioRxiv · Aug 3, 2022 · PreprintBiophysics

The Conformational Plasticity of the Selectivity Filter Methionines Controls the In-Cell Cu(I) Uptake through the CTR1 transporter

P. Janos, J. Aupic, S. Ruthstein, A. Magistrato

This paper reveals how the conformational plasticity of Met residues in CTR1 regulates Cu(I) uptake by acting as a gate that slows import when two Cu(I) ions bind.

bioRxiv · Nov 4, 2021Biochemistry

Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics

A. Meir, V. Lepechkin-Zilbermintz, S. Kahremany, F. Schwerdtfeger, L. Gevorkyan-Airapetov, A. Munder, O. Viskind, A. Gruzman, S. Ruthstein

This study develops peptide inhibitors targeting the bacterial copper efflux system CusCFBA to combat antibiotic resistance by exploiting copper toxicity.

bioRxiv · Sep 9, 2019Biochemistry

Exploring the role of the various methionine residues in the Escherichia coli CusB adapter protein

A. Meir, G. Walke, F. Schwerdtfeger, L. Gevorkyan Airapetov, S. Ruthstein

The paper investigates the role of methionine residues in the Escherichia coli CusB protein using structural and cell experiments.

PLOS ONE · Aug 29, 2019Peer-reviewedBiophysics