The Conformational Plasticity of the Selectivity Filter Methionines Controls the In-Cell Cu(I) Uptake through the CTR1 transporter
P. Janos, J. Aupic, S. Ruthstein, A. Magistrato
This paper reveals how the conformational plasticity of Met residues in CTR1 regulates Cu(I) uptake by acting as a gate that slows import when two Cu(I) ions bind.
bioRxiv · Nov 4, 2021Biochemistry