Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
X. Zhuang, J. Woods, Y. Ji, S. Scheich, F. Mo, M. Voss, H. Urlaub, K.-T. Pan, E. O. Long
The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.
bioRxiv · Apr 3, 2023 · PreprintImmunology