Y. Ji

Dynamic B0 field shimming for improving pseudo-continuous arterial spin labeling at 7 Tesla

This paper develops a dynamic B0 field shimming method for 7T PCASL to improve labeling efficiency and perfusion signal by correcting off-resonance in brain-feeding arteries.

Confidence-Enhanced Semi-supervised Learning for Mediastinal Neoplasm Segmentation

This paper introduces a confidence-enhanced semi-supervised learning framework for mediastinal neoplasm segmentation, improving performance by leveraging unlabeled data and refining prediction reliability.

Accelerating CAR T cell manufacturing with an automated next-day process

This study introduces an automated 24-hour CAR T cell manufacturing process that increases naive/stem-cell like T cells and cytotoxic activity, potentially improving therapy efficacy and patient access.

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

Anatomics MLT, an AI tool for large scale quantification of ultrastructural traits

The paper develops an AI tool for quantifying ultrastructural traits from 3D microscopic datasets and improves fixation protocols for plants.

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

The ZmHSF20-ZmHSF4-ZmCesA2 module regulates heat stress tolerance in maize

The paper identifies a regulatory module involving ZmHSF20, ZmHSF4, and ZmCesA2 that modulates heat stress tolerance in maize by balancing growth and defense mechanisms.

Evolutionary innovation in conserved regulatory elements across the mammalian tree of life

The paper identifies accelerated evolution in conserved enhancer elements across mammals and links it to regulatory function turnover and developmental gene modifications.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Cellular COPI components promote geminivirus infections by facilitating the chloroplast localization of viral C4/AC4 proteins

This study identifies the COPI pathway's role in transporting geminiviral C4/AC4 proteins to chloroplasts, facilitating infection and suggesting COPI manipulation as an antiviral strategy.

SCF cyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair

The paper identifies SCF cyclin F's role in regulating EXO1 degradation to control cell cycle-dependent DSB repair pathways.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

Beclin1-Deficient Adipocytes Promote Tumor Progression by YAP/TAZ-dependent Adipocyte Transformation

This study shows that Beclin1-deficient adipocytes promote tumor progression via YAP/TAZ signaling, and inhibiting this pathway reduces tumor growth in mice.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells

The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

MC1R reduces scarring and rescues stalled healing in a preclinical chronic wound model

This study shows that MC1R agonist reduces scarring and improves healing in a chronic wound model by enhancing angiogenesis, lymphangiogenesis, and reducing inflammation.

Cell Dynamic Mechanics Regulates Large-spatial Isotropic Matrix Modeling with Computational Simulations

The paper uses computational simulations to study how cell mechanics regulate isotropic collagen matrix modeling at large spatial scales, revealing key cellular mechanisms involved.

Structure of a G protein-coupled receptor with GRK2 and a biased ligand

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

Extracting abundance information from DNA-based data

The paper addresses biases in DNA-based data to improve within-species abundance estimation using spike-ins and a model-based estimator.

Synthesis and Evaluation of Acridone and Xanthone Epoxides with Anti-MRSA and Anti-MSSA Activity

The paper synthesizes and evaluates acridone and xanthone epoxides for anti-MRSA and anti-MSSA activity, finding that bis-epoxy derivatives show peak activity while tri-epoxy derivatives decrease activity and toxicity.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.