Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover
S. Duan, S. Sheriff, U. B. Elvis-Offiah, T. W. Sawyer, S. Sundaresan, T. Cierpicki, J. Grembecka, J. L. Merchant
This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.
bioRxiv · Dec 20, 2022 · PreprintCancer Biology