Cancer BiologybioRxivPreprint
Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover
S. Duan, S. Sheriff, U. B. Elvis-Offiah…·J. L. Merchant
This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.
DOI 10.1101/2022.12.20.521296