Author

S. Simoncelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

D. J. Williamson· 2 shared A. Caceres· 1 shared A. M. Szalai· 1 shared A. P. Cope· 1 shared A. Samadi· 1 shared B. Siarry· 1 shared C. Bray· 1 shared D. M. Owen· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

D. J. Williamson

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Author profile →

3 papers

Recent·Most cited

Extracellular ATP drives pancreatic cancer cell invasion via purinergic receptor-integrin interactions

E. Tomas Bort, M. Joseph, Q. Wang, E. Carter, N. Roth, J. Gibson, A. Samadi, H. Kocher, S. Simoncelli, P. J. McCormick, R. P. Grose

This study identifies P2RY2 as a key purinergic receptor involved in pancreatic cancer invasion through interactions with integrins, suggesting therapeutic targeting potential.

bioRxiv · Oct 24, 2022Cancer Biology

Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules

A. M. Szalai, B. Siarry, J. Lukin, D. J. Williamson, N. Unsain, D. Refojo, A. Caceres, M. Pilo-Pais, G. Acuna, D. M. Owen, S. Simoncelli, F. D. Stefani

This paper introduces SIMPLER, a method to achieve nanometric axial resolution in 3D single-molecule localization microscopy without hardware changes to TIRF microscopes.

bioRxiv · Apr 17, 2020Biophysics

Multi-colour DNA-qPAINT reveals how Csk nano-clusters regulate T-cell receptor signalling

S. Simoncelli, j. Griffie, D. J. Williamson, J. Bibby, C. Bray, R. Zamoyska, A. P. Cope, D. Owen

The paper uses DNA-qPAINT to study Csk nano-clusters in T-cells, finding they regulate signaling by re-recruiting after stimulation and interacting with PTPN22.

bioRxiv · Nov 27, 2019 · PreprintImmunology